Space processes for extended low-G testing

Results of an investigation of verifying the capabilities of space processes in ground based experiments at low-g periods are presented. Limited time experiments were conducted with the processes. A valid representation of the complete process cycle was achieved at low-g periods ranging from 40 to 390 seconds. A minimum equipment inventory, is defined. A modular equipment design, adopted to assure low cost and high program flexibility, is presented as well as procedures and data established for the synthesis and definition of dedicated and mixed rocket payloads

Sensitive and specific detection of Trypanosoma cruzi DNA in clinical specimens using a multi-target real-time PCR approach

Background: The laboratory diagnosis of Chagas disease is challenging because the usefulness of different diagnostic tests will depend on the stage of the disease. Serology is the preferred method for patients in the chronic phase, whereas PCR can be successfully used to diagnose acute and congenital cases. Here we present data using a combination of three TaqMan PCR assays to detect T. cruzi DNA in clinical specimens. Methods/Principal Findings: Included in the analysis were DNA extracted from 320 EDTA blood specimens, 18 heart tissue specimens, 6 umbilical cord blood specimens, 2 skin tissue specimens and 3 CSF specimens. For the blood specimens both whole blood and buffy coat fraction were analyzed. The specimens were from patients living in the USA, with suspected exposure to T. cruzi through organ transplantation, contact with triatomine bugs or laboratory accidents, and from immunosuppressed patients with suspected Chagas disease reactivation. Real-time PCR was successfully used to diagnose acute and Chagas disease reactivation in 20 patients, including one case of organ-transmitted infection and one congenital case. Analysis of buffy coat fractions of EDTA blood led to faster diagnosis in six of these patients compared to whole blood analysis. The three real-time PCR assays produced identical results for 94% of the specimens. The major reason for discrepant results was variable sensitivity among the assays, but two of the real-time PCR assays also produced four false positive results. Conclusions/Significance: These data strongly indicate that at least two PCR assays with different performances should be combined to increase the accuracy. This evaluation also highlights the benefit of extracting DNA from the blood specimen's buffy coat to increase the sensitivity of PCR analysis.Fil: Qvarnstrom, Yvonne. Centers for Disease Control and Prevention; Estados UnidosFil: Schijman, Alejandro Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Veron, Vincent. Centre hospitalier Andrée-Rosemon; Guayana FrancesaFil: Aznar, Christine. Centre hospitalier Andrée-Rosemon; Guayana FrancesaFil: Steurer, Francis. Centers for Disease Control and Prevention; Estados UnidosFil: da Silva, Alexandre J.. Centers for Disease Control and Prevention; Estados Unido

Waveform-level time-domain simulation comparison study of three shipboard power system architectures

Detailed waveform-level modeling and simulation of three alternative shipboard power system architectures is presented herein. The three system architectures are based on conventional 60Hz medium-voltage ac (MVAC), higherfrequency 240Hz medium-voltage ac (HFAC) and mediumvoltage dc (MVDC) technologies. To support the quantitative assessment and comparison of these three different power system architectures, each technology was modeled using a common representative, notional baseline ship. The baseline ship represents a multi-mission destroyer fitted with an 80MW next generation integrated power system (NGIPS). Modeling of each power system architecture is set forth along with simulation studies for three fault scenarios. Each of the three power system architectures was implemented within the MATLAB/ Simulink environment. Continuity of service was evaluated for each architecture along with a fault scenario using an operability metric. After a brief description of the three power system architectures and the operability metric, quantitative results are presented.Center for Electromechanic

Owner Occupied Housing in the CPI and its Impact on Monetary Policy during Housing Booms and Busts

The treatment of owner-occupied housing (OOH) is probably the most important unresolved issue in inflation measurement. How -- and whether -- it is included in the Consumer Price Index (CPI) affects inflation expectations, the measured level of real interest rates, and the behavior of governments, central banks and market participants. We show that none of the existing treatments of OOH are fit for purpose. Hence we propose a new simplified user cost method with better properties. Using a micro-level dataset, we then compare the empirical behavior of eight different treatments of OOH. Our preferred user cost approach pushes up the CPI during housing booms (by 2 percentage points or more). Our findings relate to the following important debates in macroeconomics: the behavior of the Phillips curve in the US during the global financial crisis, and the response of monetary policy to housing booms, secular stagnation, and globalization.Series: Department of Economics Working Paper Serie

Comments on "‘Screening' for Breast Cancer: Misguided Research Misinforming Public Policies” by O. S. Miettinen

From the writings in medical journals and newspapers, for many decades already, it has seemed uncertain whether programs of mammographic screening reduce mortality from breast cancer. Reviewers of the evidence, in the Cochrane Collaboration in particular, have repeatedly concluded that there is no clear evidence supporting such screening. But their results and conclusions have not impressed the advocates who continue to believe that it does reduce mortality from the cancer

Cross-platform validation of notional baseline architecture models of naval electric ship power systems

To support efforts in assessing the relative merit of alternative power system architectures for future naval combatants, the Electric Ship Research and Development Consortium (ESRDC) has developed notional baseline models for each of the primary candidate architectures currently considered, medium-voltage DC (MVDC), conventional 60 Hz medium-voltage (MVAC), and high-frequency medium-voltage (HFAC). Initial efforts have focused on the development of a consistent set of component models, of which the system models can be comprised, and the basic definition of the system models. The broader objectives of the consortium, however, go beyond the definition of the baseline models. The focus is on the process by which the models are implemented in software and validated, the process by which the performance of the disparate system models are objectively and quantitatively assessed and compared, and, ultimately, the process by which the relative merits of the architectures may be assessed. This paper focuses specifically on cross-platform component validation.Center for Electromechanic

Processes for space manufacturing - Definition of criteria for process feasibility and effectiveness Final report

Feasibility criteria and research and development program for manufacturing processes in orbital environment